Residual Psychomotor Effects following Reversal of Midazolam Sedation with Flumazenil
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چکیده
منابع مشابه
Midazolam sedation reversed with flumazenil for cardioversion.
Midazolam was used for anaesthesia in 20 patients undergoing cardioversion; 10 received flumazenil, which caused immediate rapid reversal of anaesthesia, and these patients maintained SpO2 greater than 95%, breathing air, within 5-10 min. In contrast, patients in the placebo group were still partially sedated and required oxygen therapy for up to 2 h to maintain a normal SpO2. Arterial pressure...
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The purpose of this study was to evaluate the effects of flumazenil (1 mg i.v.) on the ventilatory response of premedicated patients receiving a continuous infusion of midazolam for sedation. After assessing baseline ventilatory function using a modified Read rebreathing method for determining hypercapnic ventilatory drive, 16 healthy outpatients were administered fentanyl, 50 micrograms i.v., ...
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In this study we assessed the discriminative stimulus, self-reported, and performance effects of flumazenil in humans. The first group (n = 6) was trained to discriminate flumazenil (0.56 mg/70 kg i.v.) from saline and tested with flumazenil (0.10, 0.32, 0.56, and 1.0 mg/70 kg) under a two-response drug discrimination procedure. The second group (n = 8) was trained to discriminate flumazenil (0...
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We have studied the effect of i.v. flumazenil 0.01 mg kg-1 on the amnesia and sedation caused by midazolam 2 mg and 5 mg i.v. in volunteers in order to determine the relationship between the actions of the antagonist on these two effects. Midazolam caused dose-dependent central neural depression as assessed by critical flicker fusion frequency, and dose-dependent amnesia for word cards. In subj...
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ژورنال
عنوان ژورنال: Anaesthesia and Intensive Care
سال: 1989
ISSN: 0310-057X,1448-0271
DOI: 10.1177/0310057x8901700309